Semaglutide (injectable)
Summary
What conditions semaglutide is used for
Semaglutide is used to treat type 2 diabetes, which is a condition where the body doesn't use insulin properly, and for weight management in adults who are overweight or have obesity. It helps control blood sugar levels and supports weight loss when combined with diet and exercise.
How semaglutide works in the body
Semaglutide works by mimicking a hormone called GLP-1, which helps regulate blood sugar. It increases insulin release when blood sugar is high and reduces sugar production by the liver. It also slows digestion, making you feel full longer and reducing appetite.
Directions for Use
Semaglutide is usually taken once a week. It is injected under the skin in the stomach, thigh, or upper arm. The starting dose is typically 0.25 mg per week, increasing to 0.5 mg after four weeks, and can go up to 1 mg if needed.
The most commonly observed adverse effects of semaglutide
Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation, which are usually mild and decrease over time. These effects are related to its action on the digestive system, which slows down digestion and affects appetite.
Warnings and Precautions
Semaglutide may increase the risk of thyroid tumors, including cancer, in animal studies. It is not recommended for people with a history of medullary thyroid carcinoma, which is a type of thyroid cancer, or Multiple Endocrine Neoplasia syndrome type 2.
Drug Status
Government Approvals
WHO Essential Medicine
Known Teratogen
Pharmaceutical Class
